Illuminating a New Era of Protein Purification
• High-throughput • High Protein Yield • Simplicity
LUMERA - Multi-Channel Protein Purification System
Purify up to 8 samples in parallel with real-time UV detection —
up to 40X faster than manual protein purification.
LUMERA™ is an automated protein purification system engineered for biotechnology, pharmaceutical, academic, and government research labs that need to scale throughput without scaling headcount. Unlike traditional single-channel FPLC systems, LUMERA processes up to 8 protein samples simultaneously, using positive-pressure liquid delivery for consistent, synchronized results.
Integrated real-time UV detection at 280 nm provides live visibility into column loading, breakthrough, and elution phases, eliminating manual sampling and guesswork. LUMERA's automated flow-through re-application - a capability unique to this platform that recovers unbound target protein and maximizes resin utilization, significantly improving overall protein yield compared to a standard gravity-column or FPLC workflow.
The system supports 9 buffer solutions and is compatible with pre-packed columns (including GE HiTrap), self-poured columns, gravity-flow columns, and standard SPE cartridges.
Applications span antibody purification, IMAC/His-tag purification, ion exchange chromatography (IEX), hydrophobic interaction chromatography (HIC), and oligonucleotide purification.
Why LUMERA
Lumera™ redefines automated protein purification with a compact multi-channel design that maximizes throughput and protein yields while keeping workflows simple and efficient.
Multi-Channel High Throughput Purification
LUMERA processes up to 8 protein samples simultaneously, each up to 1 litre, in a single unattended run. This represents a step-change in daily output without additional instrument overhead or operator time.
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Integrated Real-Time UV Detection
Integrated UV monitoring at 280 nm delivers live visibility into every stage of the purification: column loading, breakthrough point, and peak elution. Unlike systems that require manual fraction sampling after the run, LUMERA lets researchers make data-driven decisions in real time and reduce post-run analysis time.
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Automated Flow-Through Re-Application to Maximize Protein Yield
LUMERA's automated flow-through re-application recovers unbound target protein that would be lost in a standard bind-and-elute workflow. By automatically re-applying flow-through fractions, LUMERA maximizes resin utilization and overall yield, particularly valuable when working with low-expression constructs or expensive affinity resins.
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LUMERA Applications: What Can You Purify?
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Antibody Purification
LUMERA supports Protein A, Protein G, and Protein L affinity purification of monoclonal antibodies, polyclonal antibodies, and antibody fragments. Purify up to 8 antibody batches in parallel -- ideal for early-stage screening and clone selection workflows
Ion Exchange & Hydrophobic Interaction Chromatography
LUMERA is compatible with cation exchange (CEX), anion exchange (AEX), and hydrophobic interaction chromatography (HIC) resins from all major manufacturers. Use LUMERA for polishing steps, charge-variant screening, or high-throughput method development across multiple conditions in one run.
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IMAC / His-Tag Protein Purification
Run parallel IMAC purifications of His-tagged recombinant proteins across 8 channels simultaneously using Ni-NTA, Co-NTA, or Cu-NTA resins. LUMERA's automated flow-through re-application recovers unbound His-tagged protein missed in a standard single-pass workflow.
Oligonucleotide & Small Biomolecule Purification
Beyond proteins, LUMERA supports purification of oligonucleotides, metabolites, and other biomolecules using standard SPE cartridge formats -- extending the instrument's utility across a broader range of lab workflows.
Engineered for a New Era
Multi-Channel & Parallel Purification for Higher Productivity
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Purify up to 8 clarified extracts simultaneously
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Higher throughput than single-channel FPLC systems
Real-Time UV Detection & Data-Driven Decisions
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Live visibility into protein binding, breakthrough, and elution
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No manual sampling
Flow-Through
Re-Application (Maximize
Yield)
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Automated flow-through
re-application recovers unbound target protein -
Ensures more complete binding and maximizes resin utilization
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Extensive Column Compatibility
with Pre-packed columns( GE HiTrap™) and Self-packed columns, gravity-flow columns, and standard SPE cartridges, supporting a wide range of affinity, ion exchange, hydrophobic interaction and other applications.
Built for the Modern Lab
Intuitive, Standalone Operation
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Integrated touchscreen with UV trace visualization
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No external PC required
Compact and Lab-Friendly Design
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Small bench-top footprint
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Cold-room / cabinet compatible
Frequently Asked Questions
1. What proteins can LUMERA purify?
LUMERA supports antibodies, enzymes, His-tagged recombinant proteins, oligonucleotides, and other biomolecules using affinity, IMAC, IEX, HIC, and SPE chromatography formats.
2. How does LUMERA compare to a traditional FPLC system?
Unlike single-channel FPLC systems that process one sample at a time, LUMERA purifies up to 8 clarified extracts simultaneously, delivering far higher throughput for the same hands-on time.
3. What columns does LUMERA support?
LUMERA is compatible with pre-packed columns (including GE HiTrap), self-poured columns, gravity-flow columns, and standard SPE cartridges.
4. What is flow-through re-application?
Flow-through re-application is a LUMERA exclusive feature that automatically re-loads flow-through fractions onto the column to recover unbound target protein, maximizing resin utilization and overall protein yield.
5. Does LUMERA require an external computer?
No. LUMERA features an integrated touchscreen with UV trace visualization and operates as a standalone instrument. No external PC or software license is required.
